What Is Amphetamine?Īmphetamine was first discovered in 1887. Tell him or her that you take kratom regularly and you’re wondering about adding an amphetamine into the mix. If you still want to mix these two substances, be sure to speak to your doctor. It’s unsafe to mix kratom and stimulants like amphetamine. Is It Safe to Take Kratom With Amphetamine? Other related stimulants kratom will interact with include: The chances of interaction between kratom and stimulants such as Ritalin and Vyvanse are comparable to mixing kratom and Adderall. There are several other stimulants, ranging from those that people use daily to illegal narcotics. They work by increasing the activity of neurotransmitters in the brain, such as dopamine, norepinephrine, and glutamate. Other Similar StimulantsĪmphetamine is just one of a large and diverse class of drugs called stimulants. This prolongs the length of time the drugs remain in the body and can accumulate.Īccumulation can lead to overdose or severe side effects. Enzymes can only metabolize so much at a time, and the process gets bogged down. Drugs that are metabolized by the same enzymes are forced to compete. Kratom and amphetamine are both metabolized by CYP2D6. Metabolic Competitor (Slowed Elimination) In this sense, kratom could diminish the effects of amphetamine, making it less effective. This could negate the effects of Adderall, making it ineffective for treating the condition it was prescribed for. On the flip side, antagonistic interactions are from two drugs that have opposite effects and essentially cancel each other out or reduce the effects. Antagonistic Interaction (Decreased Effect) Taking a low dose of kratom along with amphetamine could cause overstimulation and increase the risks for serious side effects. In this case, kratom and amphetamine are stimulants. This type of interaction happens when two drugs do the same thing, causing more extreme effects. There are three ways kratom could interact with amphetamine. In the worst case, this combination could lead to a heart attack or stroke. Taking both stimulants together could cause side effects ranging from rapid heart rate, arrhythmias, dizziness, headaches, nausea, loss of appetite, and more. Yes, kratom is likely to interact with amphetamine (Adderall).
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